Five people - one believed to be a baby - have died in a head-on crash between a lorry and a car on the A18 near Grimsby.
The victims, who were travelling in a Nissan Primera, are thought to be a family from Durham. Three died at the scene and two later in hospital.
The driver of the lorry sustained minor injuries, Humberside Police said.
Three ambulances and an air ambulance were sent to the accident at Laceby at 12.30pm.
James Cartwright, a spokesman for Humberside police, said in as statement: "Police were called today at 1230 hours following reports of a serious collision which involved a Nissan Primera car and a light goods vehicle which happened near to the Oaklands Hotel on the A18 Grimsby Rd near Laceby.
"The road remains closed at this time as officers carry out the initial investigation in order to establish how the collision occurred.
"Five people, who are all thought to have been known to each other, were travelling in the car at the time of the collision. Two of these were taken to the Diana Princess of Wales Hospital but sadly pronounced dead a short time later.
"The other three who were travelling in the vehicle at the time were pronounced dead at the scene. All are thought to have been from the Durham area."
Operations Superintendent Tracy Bradley said it was too early to speculate as to what caused the accident.
Jason Abrams, a golfer at the nearby Laceby Manor Golf Club, told ITV News: "All we know is that there's been four adults and one baby killed in the accident.
"It's a bendy road but people do go at a great lick along it. It's 60mph at the moment but the council are looking at changing it to 50 and hopefully this will make a difference.
"A car went into an articulated lorry. All we know is what the police have said - that the car tried to overtake something or the car hit a curb which has sent it spinning out of control and obviously gone head-on into a lorry."
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